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8.2.58.29 tblish.dataset.Indometh ¶

Static Method: out = Indometh () ¶

Pharmacokinetics of Indomethacin

Description ¶

Data on the pharmacokinetics of indometacin (or, older spelling, ‘indomethacin’).

Format ¶

Subject

Subject identifier.

time

Time since drug administration at which samples were drawn (hours).

conc

Plasma concentration of indomethacin (mcg/ml).

Details ¶

Each of the six subjects were given an intravenous injection of indometacin.

Source ¶

Kwan, Breault, Umbenhauer, McMahon and Duggan (1976). Kinetics of Indomethacin absorption, elimination, and enterohepatic circulation in man. Journal of Pharmacokinetics and Biopharmaceutics 4, 255–280.

Davidian, M. and Giltinan, D. M. (1995). Nonlinear Models for Repeated Measurement Data. London: Chapman & Hall. (section 5.2.4, p. 129)

Pinheiro, J. C. and Bates, D. M. (2000). Mixed-effects Models in S and S-PLUS. New York: Springer.